Human growth hormone (HGH), also known as somatotropin, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration. As we age, our bodies produce less HGH, leading to health declines associated with aging.
Several peptide supplements on the market today mimic the effects of HGH. The peptides considered closest to actual HGH are:
- Ipamorelin - A growth hormone releasing peptide (GHRP) that binds receptors in the brain to stimulate HGH release. Shown to increase growth hormone and IGF-1 levels significantly.
- CJC-1295 - A synthetic peptide that increases pulsatile HGH release. Studies show increased bone density, fat loss, and muscle gains from CJC-1295 supplementation.
- Sermorelin - A natural peptide identical to a portion of the growth hormone releasing hormone (GHRH). Binds to receptors on the pituitary gland to increase HGH production.
Key factors that determine how close a peptide is to HGH:
- Mechanism of action - The pathway it uses to stimulate HGH secretion. Peptides using the body's natural GHRH pathway are closest.
- HGH and IGF-1 release - The degree to which the peptide boosts circulating levels of these anabolic hormones.
- Clinical effects - The peptide's ability in studies to replicate benefits of HGH like fat loss, healing, and anti-aging.
Based on these criteria,
Sermorelin could be considered the peptide closest to actual HGH in mechanism and clinical effects. As an analogue of only the 1-29 amino acid chain of GHRH, Sermorelin leverages the body's natural growth hormone release pathways. Multiple studies confirm Sermorelin's HGH/IGF-1 boosting effects and benefits for building muscle, burning adipose tissue, improving skin quality, and slowing signs of aging.
Other top peptides similar to HGH
- Tesamorelin - A GHRH derivative and releasing hormone analogue. Stimulates growth hormone in a similar fashion as HGH. Clinical trials show enhanced fat metabolism and improved lipid profiles.
- AOD 9604 - Peptide fragment of the C-terminus of HGH. Shown in studies to have fat loss and anti-obesity activity comparable to HGH, as well as cartilage repair benefits. Does not stimulate IGF-1 or growth-promoting effects.
- CJC-1295 Ipamorelin - Combining these two synergistic peptides leads to huge growth hormone pulses mimicking normal pituitary GH release. The most powerful peptide stack for muscle gain, injury healing, anti-aging effects, and metabolism.
If you are considering peptide therapy to stimulate natural HGH production and amplify its myriad health and anti-aging effects, consult with a knowledgeable professional.
The experts at Prime Hormone Solutions offer free consultations to help you determine if peptides are right for your health and wellness goals. Their state-of-the-art Pituitary Performance blood test profiles over 50 biomarkers to scientifically gauge your hormone levels. If you qualify medically, their licensed healthcare providers can provide precisely dosed Sermorelin, Ipamorelin, and other pharmaceutical-grade peptide protocols tailored to your individual needs. Reach out today to see if their proven programs can help you look better, feel younger, and live optimally!